Regulatory T-cells as tumor-promoting cellular partners and potential therapeutic targets in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy of the mature B-cell that can affect both lymphoid and nonlymphoid organs. Since targeted treatments beyond monoclonal antibodies and CAR T-cells are in clinical development but not yet approved, DLBCL remains fatal in a third of patients. Many DLBCLs are infiltrated by large numbers of regulatory […]
Exploring the potential of targeting IL-21/IL-21R signaling to eliminate human acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are the origin of any myeloid leukemia and are thought to reside at the top of the leukemic hierarchy. LSCs are often resistant against standard treatment and against immune control due to various escape mechanisms. Therefore, they represent a major obstacle for the cure of leukemia. To develop new therapeutic strategies, […]